Frame, M.C., Fincham, V.J., Carragher, N.O. and Wyke, J.A. (2002) V-SRC'S hold over actin and cell adhesions. Nature Reviews Molecular Cell Biology, 3(4), pp. 233-245. (doi: 10.1038/nrm779)
Full text not currently available from Enlighten.
Abstract
The oncoprotein v-Src and its cellular homologue (c-Src) are tyrosine kinases that modulate the actin cytoskeleton and cell adhesions. Through the concerted action of their protein-interaction and kinase domains, they are targeted to cell–matrix integrin adhesions or cadherin-dependent junctions between epithelial cells, where they phosphorylate substrates that induce adhesion turnover and actin re-modelling. Recent experiments have defined some of the key targets and effector pathways that mediate the pleiotropic oncogenic effects of v-Src.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Frame, Prof Margaret |
| Authors: | Frame, M.C., Fincham, V.J., Carragher, N.O., and Wyke, J.A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Nature Reviews Molecular Cell Biology |
University Staff: Request a correction | Enlighten Editors: Update this record
Deposit and Record Details
Deposit and Record Details