McLean, G.W., Carragher, N.O., Avizienyte, E., Evans, J., Brunton, V.G. and Frame, M.C. (2005) The role of focal-adhesion kinase in cancer. A new therapeutic opportunity. Nature Reviews Cancer, 5(7), pp. 505-515. (doi: 10.1038/nrc1647)
Full text not currently available from Enlighten.
Abstract
Focal-adhesion kinase (FAK) is an important mediator of growth-factor signalling, cell proliferation, cell survival and cell migration. Given that the development of malignancy is often associated with perturbations in these processes, it is not surprising that FAK activity is altered in cancer cells. Mouse models have shown that FAK is involved in tumour formation and progression, and other studies showing that FAK expression is increased in human tumours make FAK a potentially important new therapeutic target.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Brunton, Dr Valerie and Frame, Prof Margaret |
| Authors: | McLean, G.W., Carragher, N.O., Avizienyte, E., Evans, J., Brunton, V.G., and Frame, M.C. |
| College/School: | College of Medical Veterinary and Life Sciences |
| Journal Name: | Nature Reviews Cancer |
University Staff: Request a correction | Enlighten Editors: Update this record
Deposit and Record Details
Deposit and Record Details