Melino, G., De Laurenzi, V. and Vousden, K. (2002) p73: Friend or foe in tumorigenesis. Nature Reviews Cancer, 2(8), pp. 605-615. (doi: 10.1038/nrc861)
Full text not currently available from Enlighten.
Abstract
As p53 and its homologue p73 have significant sequence and functional similarities, p73 might also be expected to act as a tumour suppressor. However, p73 is activated after DNA damage in a way that is distinct from that of p53. The existence of DeltaNp73 — an isoform of p73 that is encoded by a distinct promoter and that lacks the transactivation domain — further complicates matters. It seems to function as an oncogene by inhibiting both p73- and p53-induced apoptosis. So how can these opposing functions be reconciled in human tumours?
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Vousden, Karen |
| Authors: | Melino, G., De Laurenzi, V., and Vousden, K. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Nature Reviews Cancer |
| ISSN: | 1474-175X |
University Staff: Request a correction | Enlighten Editors: Update this record
Altmetric
Altmetric