Dervin, S., Ganguly, P. and Dahiya, R. S. (2021) Disposable electrochemical sensor using graphene oxide – chitosan modified carbon-based electrodes for the detection of tyrosine. IEEE Sensors Journal, 21(23), pp. 26226-26233. (doi: 10.1109/JSEN.2021.3073287)
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Abstract
Despite the many recent advances in disposable and wearable sensing technologies for point of care testing (POCT), few affordable, flexible, and disposable sensors are available for the detection of tyrosine (Tyr), a valuable biomarker for metabolic and neurodegenerative diseases. In this regard, the disposable screen-printed electrodes on flexible substrates are attractive. However, current screen-printed approaches for the detection of Tyr use rigid ceramic substrates, expensive metal nanoparticle conductive inks and stiff metal or metal oxide-based sensitive materials, that are not suitable for single-use disposable or wearable POCT devices. To address these challenges, this work presents a flexible and disposable electrochemical sensor using graphene oxide – chitosan (GO-CS) modified carbon-based electrodes for the detection of Tyr. The affordable and easy to fabricate sensor consists of a three-carbon electrode system screen printed on a flexible, low-cost polyvinyl chloride (PVC) substrate. GO and CS were chosen as the sensitive nanocomposite due to their natural abundance and excellent electrochemical sensing properties. Quantitative determination of Tyr using DPV revealed a linear proportional response between 1 and 100 μM, with a correlation coefficient of 0.9993. The GO-CS-screen-printed carbon sensor (SPCS) also offers a linear range detection limit of 5.86 μM, and excellent sensitivity (0.0846 μA μM-1) and repeatability (RSD = 4.02%). The GO-CS-SPCS thereby provides a promising platform for the active sensing elements of single-use, disposable, and wearable POCT devices suitable for early diagnosis and monitoring of metabolic or neurodegenerative diseases or nutritional management.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Ganguly, Ms Priyanka and Dahiya, Professor Ravinder and Dervin, Miss Saoirse |
Authors: | Dervin, S., Ganguly, P., and Dahiya, R. S. |
College/School: | College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering |
Journal Name: | IEEE Sensors Journal |
Publisher: | IEEE |
ISSN: | 1530-437X |
ISSN (Online): | 1558-1748 |
Published Online: | 14 April 2021 |
Copyright Holders: | Copyright © 2021 IEEE |
First Published: | First published in IEEE Sensors Journal 21(23): 26226-26233 |
Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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