Lucas-Herald, A. K. et al. (2021) Gonadectomy in conditions affecting sex development – a registry-based cohort study. European Journal of Endocrinology, 184(6), pp. 791-801. (doi: 10.1530/EJE-20-1058) (PMID:33780351)
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Abstract
Objectives: To determine trends in clinical practice for individuals with DSD requiring gonadectomy. Design: Retrospective cohort study. Methods: Information regarding age at gonadectomy according to diagnosis; reported sex; time of presentation to specialist center; and location of center from cases reported to the International DSD Registry and who were over 16 years old in January 2019. Results: Data regarding gonadectomy were available in 668 (88%) individuals from 44 centers. Of these, 248 (37%) (median age (range) 24 (17, 75) years) were male and 420 (63%) (median age (range) 26 (16, 86) years) were female. Gonadectomy was reported from 36 centers in 351/668 cases (53%). Females were more likely to undergo gonadectomy (n=311, p<0.0001). The indication for gonadectomy was reported in 268 (76%). The most common indication was mitigation of tumour risk in 172 (64%). Variations in the practice of gonadectomy were observed; of the 351 cases from 36 centers, 17 (5%) at 9 centers had undergone gonadectomy before their first presentation to the specialist center. Median age at gonadectomy of cases from high income countries and low/middle income countries (LMIC) was 13.0 yrs (0.1, 68) years and 16.5 yrs (1, 28), respectively (p<0.0001) with the likelihood of long-term retention of gonads being higher in LMIC countries. Conclusions: The likelihood of gonadectomy depends on the underlying diagnosis, sex of rearing and the geographical setting. Clinical benchmarks, which can be studied across all forms of DSD will allow a better understanding of the variation in the practice of gonadectomy.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Lucas-Herald, Dr Angela and Kyriakou, Dr Andreas and Bryce, Dr Jillian and Ahmed, Professor Syed Faisal |
| Authors: | Lucas-Herald, A. K., Bryce, J., Kyriakou, A., Lindhardt Ljubicic, M., Arlt, W., Audí, L., Balsamo, A., Baronio, F., Bertelloni, S., Bettendorf, M., Brooke, A., Claahsen-van der Grinten, H. L., Davies, J., Hermann, G., de Vries, L., Hughes, I. A., Tadokoro-Cuccaro, R., Darendeliler, F., Poyrazoglu, S., Ellaithi, M., Evliyaoglu, O., Fica, S., Stejereanu, L., Gawlik, A., Globa, E., Zelinska, N., Guran, T., Güven, A., Hannema, S., Hiort, O., Holterhus, P.-m., Iotova, V., Mladenov, V., Jain, V., Sharma, R., Jennane, F., Johnston, C., Guerra-Junior, G., Konrad, D., Gaisl, O., Krone, N. P., Krone, R., Lachlan, K., Li, D., Lichiardopol, C., Lisá, L., Levoni Markosyan, R., Mazen, I., Mohnike, K., Niedziela, M., Nordenstrom, A., Rey, R. A., Skae, M., Tack, L. J.W., Tomlinson, J. W., Weintrob, N., Cools, M., and Ahmed, S. F. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | European Journal of Endocrinology |
| Publisher: | BioScientifica |
| ISSN: | 0804-4643 |
| ISSN (Online): | 1479-683X |
| Published Online: | 01 March 2021 |
| Copyright Holders: | Copyright © 2021 The Authors |
| First Published: | First published in European Journal of Endocrinology 184(6): 791-801 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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