Ploidy dynamics increase the risk of liver cancer initiation

Müller, M., May, S. and Bird, T. G. (2021) Ploidy dynamics increase the risk of liver cancer initiation. Nature Communications, 12, 1896. (doi: 10.1038/s41467-021-21897-8) (PMID:33767143) (PMCID:PMC7994546)

[img] Text
237465.pdf - Published Version
Available under License Creative Commons Attribution.



Liver cancer typically arises after years of inflammatory insults to hepatocytes. These cells can change their ploidy state during health and disease. Whilst polyploidy may offer some protection, new research shows it may also promote the formation of liver tumours.

Item Type:Articles
Additional Information:The authors acknowledge funding from Cancer Research UK (Grant number: A17196), the Wellcome Trust (Grant number: WT107492Z) and CRUK HUNTER Accelerator Award (Grant number: A26813).
Glasgow Author(s) Enlighten ID:May, Dr Steph and Bird, Dr Thomas
Authors: Müller, M., May, S., and Bird, T. G.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Nature Communications
Publisher:Nature Research
ISSN (Online):2041-1723
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Nature Communications 12: 1896
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record

Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
301496HUNTER: Hepatocellular Carcinoma Expediter NetworkThomas BirdCancer Research UK (CRUK)BH172934 - C9380/A26813CS - Experimental Therapeutics