Müller, M., May, S. and Bird, T. G. (2021) Ploidy dynamics increase the risk of liver cancer initiation. Nature Communications, 12, 1896. (doi: 10.1038/s41467-021-21897-8) (PMID:33767143) (PMCID:PMC7994546)
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Abstract
Liver cancer typically arises after years of inflammatory insults to hepatocytes. These cells can change their ploidy state during health and disease. Whilst polyploidy may offer some protection, new research shows it may also promote the formation of liver tumours.
| Item Type: | Articles |
|---|---|
| Additional Information: | The authors acknowledge funding from Cancer Research UK (Grant number: A17196), the Wellcome Trust (Grant number: WT107492Z) and CRUK HUNTER Accelerator Award (Grant number: A26813). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | May, Dr Steph and Bird, Dr Thomas |
| Authors: | Müller, M., May, S., and Bird, T. G. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Nature Communications |
| Publisher: | Nature Research |
| ISSN: | 2041-1723 |
| ISSN (Online): | 2041-1723 |
| Copyright Holders: | Copyright © 2021 The Authors |
| First Published: | First published in Nature Communications 12: 1896 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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