Lupo, F., Ingersoll, M. A. and Pineda, M. (2021) The glycobiology of uropathogenic E. coli infection: the sweet and bitter role of sugars in urinary tract immunity. Immunology, 164(1), pp. 3-14. (doi: 10.1111/imm.13330) (PMID:33763853)
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Abstract
Urinary tract infections (UTI) are among the most prevalent infectious diseases and the most common cause of nosocomial infections, worldwide. Uropathogenic E. coli (UPEC) are responsible for approximately 80% of all UTI, which most commonly affect the bladder. UPEC colonise the urinary tract by ascension of the urethra, followed by cell invasion, and proliferation inside and outside urothelial cells, thereby causing symptomatic infections and quiescent intracellular reservoirs that may lead to recurrence. Sugars or glycans are key molecules for host‐pathogen interactions, and UTI are no exception. Surface glycans regulate many of the events associated with UPEC adhesion and infection, as well as induction of the host immune response. Whilst the bacterial protein FimH binds mannose‐containing host glycoproteins to initiate infection and UPEC‐secreted polysaccharides block immune mechanisms to favour intracellular replication, host glycans on the urothelial surface and on secreted glycoproteins prevent or limit infection by inhibiting UPEC adhesion. Given the importance of glycans during UTI, here we review the glycobiology of UPEC infection to highlight fundamental sugar‐mediated processes of immunological interest for their potential clinical applications. Interdisciplinary approaches incorporating glycomics and infection biology may help to develop novel non‐antibiotic based therapeutic strategies for bacterial infections as the spread of antimicrobial resistant uropathogens is currently threatening modern health care systems.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Pineda, Dr Miguel |
| Authors: | Lupo, F., Ingersoll, M. A., and Pineda, M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Research Centre: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology |
| Journal Name: | Immunology |
| Publisher: | Wiley |
| ISSN: | 0019-2805 |
| ISSN (Online): | 1365-2567 |
| Published Online: | 24 March 2021 |
| Copyright Holders: | Copyright © 2021 The Authors |
| First Published: | First published in Immunology 164(1): 3-14 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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