Direct imaging of glymphatic flow using H217O MRI

Alshuhri, M. S. , Gallagher, L., Work, L. and Holmes, W. (2021) Direct imaging of glymphatic flow using H217O MRI. JCI Insight, 6(10), e141159. (doi: 10.1172/jci.insight.141159) (PMID:33857020)

Abstract

The recently proposed glymphatic pathway for solute transport and waste clearance from the brain has been the focus of intense debate. By exploiting an isotopically enriched MRI tracer, H217O, we directly imaged glymphatic water transport in the rat brain in vivo for the first time. Our results reveal glymphatic transport that is dramatically faster and more extensive than previously thought and unlikely to be explained by diffusion alone. Moreover, we confirm the critical role of aquaporin-4 channels in glymphatic transport.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Work, Dr Lorraine and Gallagher, Mrs Lindsay and Holmes, Dr William and Alshuhri, Mohammed Shenan S
• Authors: Alshuhri, M. S., Gallagher, L., Work, L., and Holmes, W.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
• Journal Name: JCI Insight
• Publisher: American Society for Clinical Investigation
• ISSN: 2379-3708
• ISSN (Online): 2379-3708
• Published Online: 15 April 2021
• Copyright Holders: Copyright © 2021 Alshuhri et al.
• First Published: First published in JCI Insight 6(10): e141159
• Publisher Policy: Reproduced under a Creative Commons licence