Direct imaging of glymphatic flow using H217O MRI

Alshuhri, M. S. , Gallagher, L., Work, L. and Holmes, W. (2021) Direct imaging of glymphatic flow using H217O MRI. JCI Insight, 6(10), e141159. (doi: 10.1172/jci.insight.141159) (PMID:33857020)

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The recently proposed glymphatic pathway for solute transport and waste clearance from the brain has been the focus of intense debate. By exploiting an isotopically enriched MRI tracer, H217O, we directly imaged glymphatic water transport in the rat brain in vivo for the first time. Our results reveal glymphatic transport that is dramatically faster and more extensive than previously thought and unlikely to be explained by diffusion alone. Moreover, we confirm the critical role of aquaporin-4 channels in glymphatic transport.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Work, Dr Lorraine and Gallagher, Mrs Lindsay and Holmes, Dr William and Alshuhri, Mohammed Shenan S
Authors: Alshuhri, M. S., Gallagher, L., Work, L., and Holmes, W.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:JCI Insight
Publisher:American Society for Clinical Investigation
ISSN (Online):2379-3708
Published Online:15 April 2021
Copyright Holders:Copyright © 2021 Alshuhri et al.
First Published:First published in JCI Insight 6(10): e141159
Publisher Policy:Reproduced under a Creative Commons licence

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