Sodium-iodide symporter (NIS)-mediated accumulation of [(211)AT]astatide in NIS-transfected human cancer cells

Carlin, S., Mairs, R. , Welsh, P. and Zalutsky, M. (2002) Sodium-iodide symporter (NIS)-mediated accumulation of [(211)AT]astatide in NIS-transfected human cancer cells. Nuclear Medicine and Biology, 29(7), pp. 729-739. (doi: 10.1016/S0969-8051(02)00332-3)

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The cellular expression of the sodium iodide symporter (NIS) has been shown to confer iodide-concentrating capacity in non-thyroid cell types. We examined the role of NIS in the uptake of the alpha-particle emitting radiohalide [At-211]astatide in the UVW human glioma cell line transfected to express NIS. [At-211]Astatide uptake is shown to be NIS-dependent, with characteristics similar to [I-131]iodide uptake. These studies suggest [At-211]astatide as a possible alternative radionuclide to [I-131]iodide for NIS-based endoradiotherapy, and provide a model for the study of [At-211]astatide behavior at a cellular level.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Mairs, Professor Robert
Authors: Carlin, S., Mairs, R., Welsh, P., and Zalutsky, M.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Nuclear Medicine and Biology

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