Franz, L., Kazmaier, U., Truman, A. W. and Koehnke, J. (2021) Bottromycins - biosynthesis, synthesis and activity. Natural Product Reports, 38(9), pp. 1659-1683. (doi: 10.1039/D0NP00097C) (PMID:33621290)
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Abstract
Covering: 1950s up to the end of 2020Bottromycins are a class of macrocyclic peptide natural products that are produced by several Streptomyces species and possess promising antibacterial activity against clinically relevant multidrug-resistant pathogens. They belong to the ribosomally synthesised and post-translationally modified peptide (RiPP) superfamily of natural products. The structure contains a unique four-amino acid macrocycle formed via a rare amidine linkage, C-methylation and a d-amino acid. This review covers all aspects of bottromycin research with a focus on recent years (2009-2020), in which major advances in total synthesis and understanding of bottromycin biosynthesis were achieved.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Koehnke, Professor Jesko |
Authors: | Franz, L., Kazmaier, U., Truman, A. W., and Koehnke, J. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Natural Product Reports |
Publisher: | Royal Society of Chemistry |
ISSN: | 0265-0568 |
ISSN (Online): | 1460-4752 |
Published Online: | 23 February 2021 |
Copyright Holders: | Copyright © 2021 The Royal Society of Chemistry |
First Published: | First published in Natural Product Reports 38(9): 1659-1683 |
Publisher Policy: | Reproduced under a Creative Commons License |
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