Mitochondrial quality control: from molecule to organelle

Roca-Portoles, A. and Tait, S. W.G. (2021) Mitochondrial quality control: from molecule to organelle. Cellular and Molecular Life Sciences, 78(8), pp. 3853-3866. (doi: 10.1007/s00018-021-03775-0) (PMID:33782711) (PMCID:PMC8106605)

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Mitochondria are organelles central to myriad cellular processes. To maintain mitochondrial health, various processes co-operate at both the molecular and organelle level. At the molecular level, mitochondria can sense imbalances in their homeostasis and adapt to these by signaling to the nucleus. This mito-nuclear communication leads to the expression of nuclear stress response genes. Upon external stimuli, mitochondria can also alter their morphology accordingly, by inducing fission or fusion. In an extreme situation, mitochondria are degraded by mitophagy. Adequate function and regulation of these mitochondrial quality control pathways are crucial for cellular homeostasis. As we discuss, alterations in these processes have been linked to several pathologies including neurodegenerative diseases and cancer.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Roca, Alba and Tait, Professor Stephen
Authors: Roca-Portoles, A., and Tait, S. W.G.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Cellular and Molecular Life Sciences
ISSN (Online):1420-9071
Published Online:29 March 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Cellular and Molecular Life Sciences 78(8): 3853-3866
Publisher Policy:Reproduced under a Creative Commons licence

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
172856Apoptosis as an oncogenic process: understanding and exploiting its dark-sideStephen TaitCancer Research UK (CRUK)C40872/A21448Institute of Cancer Sciences