Dee, K., Goldfarb, D. M., Haney, J., Amat, J. A.R., Herder, V. , Stewart, M., Szemiel, A. M., Baguelin, M. and Murcia, P. R. (2021) Human rhinovirus infection blocks SARS-CoV-2 replication within the respiratory epithelium: implications for COVID-19 epidemiology. Journal of Infectious Diseases, 224(1), pp. 31-38. (doi: 10.1093/infdis/jiab147) (PMID:33754149) (PMCID:PMC8083659)
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Abstract
Virus-virus interactions influence the epidemiology of respiratory infections. However, the impact of viruses causing upper respiratory infections on SARS-CoV-2 replication and transmission is currently unknown. Human rhinoviruses cause the common cold and are the most prevalent respiratory viruses of humans. Interactions between rhinoviruses and co-circulating respiratory viruses have been shown to shape virus epidemiology at the individual host and population level. Here, we examined the replication kinetics of SARS-CoV-2 in the human respiratory epithelium in the presence or absence of rhinovirus. We show that human rhinovirus triggers an interferon response that blocks SARS-CoV-2 replication. Mathematical simulations show that this virus-virus interaction is likely to have a population-wide effect as an increasing prevalence of rhinovirus will reduce the number of new COVID-19 cases.
| Item Type: | Articles |
|---|---|
| Keywords: | SARS-CoV-2, rhinovirus, virus-virus interactions. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Amat, Julien and Szemiel, Dr Agnieszka and Herder, Dr Vanessa and Goldfarb, Mr Daniel and Haney, Joanne and Stewart, Dr Meredith and Murcia, Professor Pablo and Dee, Dr Kieran |
| Authors: | Dee, K., Goldfarb, D. M., Haney, J., Amat, J. A.R., Herder, V., Stewart, M., Szemiel, A. M., Baguelin, M., and Murcia, P. R. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | Journal of Infectious Diseases |
| Publisher: | Oxford University Press |
| ISSN: | 0022-1899 |
| ISSN (Online): | 1537-6613 |
| Published Online: | 23 March 2021 |
| Copyright Holders: | Copyright © 2021 The Authors |
| First Published: | First published in Journal of Infectious Diseases 224(1): 31-38 |
| Publisher Policy: | Reproduced under a Creative Commons License |
| Related URLs: |
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