Photoactivated release of membrane impermeant sulfonates inside cells

Caldwell, S. T. , O'Byrne, S., Wilson, C., Cvetko, F., Murphy, M. P., McCarron, J. G. and Hartley, R. C. (2021) Photoactivated release of membrane impermeant sulfonates inside cells. Chemical Communications, 57(32), pp. 3917-3920. (doi: 10.1039/D0CC07713E) (PMID:33871501) (PMCID:PMC7611313)

Abstract

Photouncaging delivers compounds with high spatial and temporal control to induce or inhibit biological processes but the released compounds may diffuse out. We here demonstrate that sulfonate anions can be photocaged so that a membrane impermeable compound can enter cells, be uncaged by photoirradiation and trapped within the cell.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Caldwell, Dr Stuart and O'Byrne, Mr Sean and Hartley, Professor Richard
• Authors: Caldwell, S. T., O'Byrne, S., Wilson, C., Cvetko, F., Murphy, M. P., McCarron, J. G., and Hartley, R. C.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: Chemical Communications
• Publisher: Royal Society of Chemistry
• ISSN: 1359-7345
• ISSN (Online): 1364-548X
• Published Online: 12 March 2021
• Copyright Holders: Copyright © 2021 The Authors
• First Published: First published in Chemical Communications 57(32): 3917-3920
• Publisher Policy: Reproduced under a Creative Commons licence

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
163913		Targeting Ca2+ Signals in intact native smooth muscle	Richard Hartley	Wellcome Trust (WELLCOTR)	092292/B/10/Z	Chemistry
172617		Exploring mitochondrial metabolism in health and disease using targeted biological chemistry	Richard Hartley	Wellcome Trust (WELLCOTR)	110158/Z/15/Z	Chemistry