Zelluläre Therapie von Autoimmunerkrankungen = Cellular therapy in autoimmune disease

Thümmler, K. , Ramming, A., Schulze-Koops, H. and Skapenko, A. (2009) Zelluläre Therapie von Autoimmunerkrankungen = Cellular therapy in autoimmune disease. Zeitschrift fur Rheumatologie, 68(4), pp. 337-339. (doi: 10.1007/s00393-009-0458-y) (PMID:19337742)

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In addition to natural thymus-derived regulatory T-cells (Tregs), peripherally-induced Tregs are of central importance in immune homeostasis. Homotypic interactions between activated effector T-cells and resting memory T-cells induced the generation of IL-10 and IFNgamma producing Tregs in vitro. This mechanism in Treg development allows new insights into T-cell vaccination, which has been employed in pilot trials of multiple sclerosis and rheumatoid arthritis with promising results.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Muecklisch, Dr Katja
Authors: Thümmler, K., Ramming, A., Schulze-Koops, H., and Skapenko, A.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Zeitschrift fur Rheumatologie
ISSN (Online):1435-1250
Published Online:02 April 2009

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