Thümmler, K. , Leipe, J., Ramming, A., Schulze-Koops, H. and Skapenko, A. (2010) Immune regulation by peripheral suppressor T cells induced upon homotypic T cell/T cell interactions. Journal of Leukocyte Biology, 88(5), pp. 1041-1050. (doi: 10.1189/jlb.0310122) (PMID:20651300)
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Abstract
We have shown previously that homotypic interaction of resting memory CD4 T cells with activated T cells induces the production of cytokines with immunoregulatory potential (IL‐10, IL‐4) from the former. Here, we analyzed the effector functions of these T cells stimulated by homotypic T cell interaction. T cells induced upon homotypic T cell interaction expressed CD25 and reduced levels of CD127 and produced TGF‐β. Functionally, homotypic T cell interaction‐induced T cells were anergic and inhibited the proliferation of CD25‐negative T cells as potently as naturally occurring CD25‐positive Tregs in vitro. They also prevented clonotypic expansion of OVA TCR tg T cells in BALB/c mice upon antigenic challenge in vivo. The generation of suppressor T cells by homotypic T cell contact is anchored and tuned through interactions of LFA‐1 and its ligands ICAM‐1, ICAM‐2, and ICAM‐3. Together, the data suggest a negative‐feedback mechanism of specific immunity involving bystander‐activated memory T cells.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Muecklisch, Dr Katja |
Authors: | Thümmler, K., Leipe, J., Ramming, A., Schulze-Koops, H., and Skapenko, A. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Journal of Leukocyte Biology |
Publisher: | Wiley |
ISSN: | 0741-5400 |
ISSN (Online): | 1938-3673 |
Published Online: | 22 July 2010 |
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