Griendling, K. K., Camargo, L. L., Rios, F. , Alves-Lopes, R., Montezano, A. C. and Touyz, R. M. (2021) Oxidative stress and hypertension. Circulation Research, 128(7), pp. 993-1020. (doi: 10.1161/CIRCRESAHA.121.318063) (PMID:33793335)
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Abstract
A link between oxidative stress and hypertension has been firmly established in multiple animal models of hypertension but remains elusive in humans. While initial studies focused on inactivation of nitric oxide by superoxide, our understanding of relevant reactive oxygen species (superoxide, hydrogen peroxide, and peroxynitrite) and how they modify complex signaling pathways to promote hypertension has expanded significantly. In this review, we summarize recent advances in delineating the primary and secondary sources of reactive oxygen species (nicotinamide adenine dinucleotide phosphate oxidases, uncoupled endothelial nitric oxide synthase, endoplasmic reticulum, and mitochondria), the posttranslational oxidative modifications they induce on protein targets important for redox signaling, their interplay with endogenous antioxidant systems, and the role of inflammasome activation and endoplasmic reticular stress in the development of hypertension. We highlight how oxidative stress in different organ systems contributes to hypertension, describe new animal models that have clarified the importance of specific proteins, and discuss clinical studies that shed light on how these processes and pathways are altered in human hypertension. Finally, we focus on the promise of redox proteomics and systems biology to help us fully understand the relationship between ROS and hypertension and their potential for designing and evaluating novel antihypertensive therapies.
| Item Type: | Articles |
|---|---|
| Additional Information: | KKG is supported by a grant from the NIH (HL152167). RMT is supported by grants from the British Heart Foundation (RE/18/6/34217, CH/4/29762). ACM is supported by a University of Glasgow Walton Fellowship. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Rios, Dr Francisco and Montezano, Dr Augusto and Touyz, Professor Rhian |
| Authors: | Griendling, K. K., Camargo, L. L., Rios, F., Alves-Lopes, R., Montezano, A. C., and Touyz, R. M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Circulation Research |
| Publisher: | American Heart Association |
| ISSN: | 0009-7330 |
| ISSN (Online): | 0009-7330 |
| Published Online: | 01 April 2021 |
| Copyright Holders: | Copyright © 2021 American Heart Association, Inc. |
| First Published: | First published in Circulation Research 128(7):993-1020 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
University Staff: Request a correction | Enlighten Editors: Update this record
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