Campbell, J., Cook, G. and Holyoake, T. (2001) Evolution of bone marrow transplantation - the original immunotherapy. Trends in Immunology, 22(2), pp. 88-92. (doi: 10.1016/S1471-4906(00)01857-3)
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Abstract
Allogeneic bone-marrow transplantation (BMT) has provided a curative treatment option for chronic myeloid leukaemia (CML) over the past 20-30 years. New drugs - signal transduction inhibitors - that target the bcr-abl oncogene have the potential to render such transplantation procedures obsolete and provide hope for those without a suitable donor (approximate to 60% of patients). Here, we discuss how new drug and immune-based approaches could be combined to enhance treatment of this already 'curable' malignancy.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Holyoake, Professor Tessa |
| Authors: | Campbell, J., Cook, G., and Holyoake, T. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Trends in Immunology |
| ISSN: | 1471-4906 |
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