Fluid-structure interaction in a fully coupled three-dimensional mitral-atrium-pulmonary model

Feng, L., Gao, H. , Qi, N., Danton, M., Hill, N. A. and Luo, X. (2021) Fluid-structure interaction in a fully coupled three-dimensional mitral-atrium-pulmonary model. Biomechanics and Modeling in Mechanobiology, (doi: 10.1007/s10237-021-01444-6) (PMID:33770307) (Early Online Publication)

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Abstract

This paper aims to investigate detailed mechanical interactions between the pulmonary haemodynamics and left heart function in pathophysiological situations (e.g. atrial fibrillation and acute mitral regurgitation). This is achieved by developing a complex computational framework for a coupled pulmonary circulation, left atrium and mitral valve model. The left atrium and mitral valve are modelled with physiologically realistic three-dimensional geometries, fibre-reinforced hyperelastic materials and fluid–structure interaction, and the pulmonary vessels are modelled as one-dimensional network ended with structured trees, with specified vessel geometries and wall material properties. This new coupled model reveals some interesting results which could be of diagnostic values. For example, the wave propagation through the pulmonary vasculature can lead to different arrival times for the second systolic flow wave (S2 wave) among the pulmonary veins, forming vortex rings inside the left atrium. In the case of acute mitral regurgitation, the left atrium experiences an increased energy dissipation and pressure elevation. The pulmonary veins can experience increased wave intensities, reversal flow during systole and increased early-diastolic flow wave (D wave), which in turn causes an additional flow wave across the mitral valve (L wave), as well as a reversal flow at the left atrial appendage orifice. In the case of atrial fibrillation, we show that the loss of active contraction is associated with a slower flow inside the left atrial appendage and disappearances of the late-diastole atrial reversal wave (AR wave) and the first systolic wave (S1 wave) in pulmonary veins. The haemodynamic changes along the pulmonary vessel trees on different scales from microscopic vessels to the main pulmonary artery can all be captured in this model. The work promises a potential in quantifying disease progression and medical treatments of various pulmonary diseases such as the pulmonary hypertension due to a left heart dysfunction.

Item Type:Articles
Additional Information:This project is funded by the UK Engineering and Physical Sciences Research Council grants (EP/S030875/1, EP/S020950, and EP/N014642).
Status:Early Online Publication
Refereed:Yes
Glasgow Author(s) Enlighten ID:Luo, Professor Xiaoyu and Qi, Dr Nan and Hill, Professor Nicholas and Gao, Dr Hao and Danton, Mr Mark and Feng, Mr Liuyang
Authors: Feng, L., Gao, H., Qi, N., Danton, M., Hill, N. A., and Luo, X.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Science and Engineering > School of Mathematics and Statistics
Journal Name:Biomechanics and Modeling in Mechanobiology
Publisher:Springer
ISSN:1617-7959
ISSN (Online):1617-7940
Published Online:26 March 2021
Copyright Holders:Copyright © The Author(s) 2021
First Published:First published in Biomechanics and Modeling in Mechanobiology 2021
Publisher Policy:Reproduced under a Creative Commons license

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
303232EPSRC Centre for Multiscale soft tissue mechanics with MIT and POLIMI (SofTMech-MP)Xiaoyu LuoEngineering and Physical Sciences Research Council (EPSRC)EP/S030875/1M&S - Mathematics
303231A whole-heart model of multiscale soft tissue mechanics and fluid structureinteraction for clinical applications (Whole-Heart-FSI)Xiaoyu LuoEngineering and Physical Sciences Research Council (EPSRC)EP/S020950/1M&S - Mathematics
172141EPSRC Centre for Multiscale soft tissue mechanics with application to heart & cancerRaymond OgdenEngineering and Physical Sciences Research Council (EPSRC)EP/N014642/1M&S - Mathematics