Main, A. and Fuller, W. (2022) Protein S‐palmitoylation: advances and challenges in studying a therapeutically important lipid modification. FEBS Journal, 289(4), pp. 861-882. (doi: 10.1111/febs.15781) (PMID:33624421)
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Abstract
The lipid post‐translational modification S‐palmitoylation is a vast developing field, with the modification itself and the enzymes that catalyse the reversible reaction implicated in a number of diseases. In this review we discuss the past and recent advances in the experiment tools used in this field, including pharmacological tools, animal models and techniques to understand how palmitoylation controls protein localisation and function. Additionally, we discuss the obstacles to overcome in order to advance the field, particularly to the point at which modulating palmitoylation may be achieved as a therapeutic strategy.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Fuller, Professor Will and Main, Miss Alice |
| Creator Roles: | |
| Authors: | Main, A., and Fuller, W. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Molecular Biosciences College of Medical Veterinary and Life Sciences > School of Life Sciences |
| Journal Name: | FEBS Journal |
| Publisher: | Wiley |
| ISSN: | 1742-464X |
| ISSN (Online): | 1742-4658 |
| Published Online: | 24 February 2021 |
| Copyright Holders: | Copyright © 2021 The Authors |
| First Published: | First published in FEBS Journal 289(4): 861-882 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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