Hemisphere-specific optogenetic stimulation reveals left-right asymmetry of hippocampal plasticity

Kohl, M. M. , Shipton, O. A., Deacon, R. M., Rawlins, J. N. P., Deisseroth, K. and Paulsen, O. (2011) Hemisphere-specific optogenetic stimulation reveals left-right asymmetry of hippocampal plasticity. Nature Neuroscience, 14(11), pp. 1413-1415. (doi: 10.1038/nn.2915) (PMID:21946328) (PMCID:PMC3754824)

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Abstract

Postsynaptic spines at CA3-CA1 synapses differ in glutamate receptor composition according to the hemispheric origin of CA3 afferents. To study the functional consequences of this asymmetry, we used optogenetic tools to selectively stimulate axons of CA3 pyramidal cells originating in either left or right mouse hippocampus. We found that left CA3 input produced more long-term potentiation at CA1 synapses than right CA3 input as a result of differential expression of GluN2B subunit–containing NMDA receptors.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kohl, Dr Michael
Authors: Kohl, M. M., Shipton, O. A., Deacon, R. M., Rawlins, J. N. P., Deisseroth, K., and Paulsen, O.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Nature Neuroscience
Publisher:Nature Research
ISSN:1097-6256
ISSN (Online):1546-1726
Published Online:25 September 2011

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