Caged intracellular NMDA receptor blockers for the study of subcellular ion channel function

Reeve, J. E., Kohl, M. M. , Rodríguez-Moreno, A., Paulsen, O. and Anderson, H. L. (2012) Caged intracellular NMDA receptor blockers for the study of subcellular ion channel function. Communicative and Integrative Biology, 5(3), pp. 240-242. (doi: 10.4161/cib.19400) (PMID:22896783) (PMCID:PMC3419105)

Abstract

We have previously synthesized a caged form of the use-dependent N-methyl-D-aspartate (NMDA) receptor ion channel blocker MK801 and used intracellular photolysis of this compound to demonstrate the subcellular location of NMDA receptor ion channels involved in synaptic plasticity. Here, we discuss considerations regarding the choice of caging molecule, synthesis and the potential uses for caged ion channel blockers in neurophysiology.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Kohl, Dr Michael
• Authors: Reeve, J. E., Kohl, M. M., Rodríguez-Moreno, A., Paulsen, O., and Anderson, H. L.
• College/School: College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
• Journal Name: Communicative and Integrative Biology
• Publisher: Landes Bioscience
• ISSN: 1942-0889
• ISSN (Online): 1942-0889
• Published Online: 01 May 2012
• Copyright Holders: Copyright © 2012 Landes Bioscience
• First Published: First published in Communicative and Integrative Biology 5(3): 240-242
• Publisher Policy: Reproduced under a Creative Commons License