Immobilising giant unilamellar vesicles with zirconium metal-organic framework anchors

Jennings, C. S., Rossman, J. S., Hourihan, B. A., Marshall, R., Forgan, R. S. and Blight, B. A. (2021) Immobilising giant unilamellar vesicles with zirconium metal-organic framework anchors. Soft Matter, 17(8), pp. 2024-2027. (doi: 10.1039/D0SM02188A) (PMID:33599656)

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Abstract

Lipid bilayer vesicles have provided a window into the function and fundamental properties of cells. However, as is the case for most living and soft matter, vesicles do not remain still. This necessitates some microscopy experiments to include a preparatory immobilisation step. Here, we describe a straightforward method to immobilise giant unilamellar vesicles (GUVs) using zirconium-based metal-organic frameworks (MOFs) and demonstrate that GUVs bound in this way will stay in position on a timescale of minutes to hours.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Forgan, Professor Ross and Marshall, Mr Ross James
Authors: Jennings, C. S., Rossman, J. S., Hourihan, B. A., Marshall, R., Forgan, R. S., and Blight, B. A.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Soft Matter
Publisher:Royal Society of Chemistry
ISSN:1744-683X
ISSN (Online):1744-6848
Published Online:09 February 2021
Copyright Holders:Copyright © 2021 The Royal Society of Chemistry
First Published:First published in Soft Matter 17(8): 2024-2027
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
168273Biomimetic guest selective metal-organic frameworks: catalysis and self-assemblyRoss ForganEngineering and Physical Sciences Research Council (EPSRC)EP/L004461/1Chemistry