Ward, S.A. (2007) Ventilatory control in humans: constraints and limitations. Experimental Physiology, 92, pp. 357-366. (doi: 10.1113/expphysiol.2006.034371)
Full text not currently available from Enlighten.
Abstract
Below the lactate threshold (θL), ventilation Graphic responds in close proportion to CO2 output Graphic to regulate arterial partial pressure of CO2 Graphic. While ventilatory control models have traditionally included proportional feedback (central and carotid chemosensory) and feedforward (central and peripheral neurogenic) elements, the mechanisms involved remain unclear. Regardless, putative control schemes have to accommodate the close dynamic ‘coupling' between Graphic and Graphic. Above θL, Graphic is driven down to constrain the fall of arterial pH by a compensatory hyperventilation, probably of carotid body origin. When Graphic requirements are high (as in highly fit endurance athletes), Graphic can attain limiting proportions. Not only does this impair gas exchange at these work rates, but there may be an associated high metabolic cost for generation of respiratory muscle power, which may be sufficient to divert a fraction of the cardiac output away from the muscles of locomotion to the respiratory muscles, further compromising exercise tolerance.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | UNSPECIFIED |
| Authors: | Ward, S.A. |
| College/School: | College of Medical Veterinary and Life Sciences |
| Journal Name: | Experimental Physiology |
University Staff: Request a correction | Enlighten Editors: Update this record
Altmetric
Altmetric