Challenges of using protein antibiotics for pathogen control

Chai, R., Rooney, W. M. , Milner, J. J. and Walker, D. (2021) Challenges of using protein antibiotics for pathogen control. Pest Management Science, (doi: 10.1002/ps.6312) (PMID:33527621) (Early Online Publication)

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Bacterial phytopathogens represent a significant threat to many economically important crops. Current control measures often inflict harm on the environment and may ultimately impact on human health through the spread of antibiotic resistance. Antimicrobial proteins such as bacteriocins have been suggested as the next generation of disease control agents since they are able to specifically target the pathogen of interest with minimal impact on the wider microbial community and environment. However, substantial gaps in knowledge with regards to the efficacy and application of bacteriocins to combat phytopathogenic bacteria remain. Here we highlight the immediate challenges the community must address to ensure maximum exploitation of antimicrobial proteins in the field.

Item Type:Articles
Status:Early Online Publication
Glasgow Author(s) Enlighten ID:Walker, Professor Daniel and Rooney, Dr Will and Milner, Dr Joel and Chai, Dr Ray
Authors: Chai, R., Rooney, W. M., Milner, J. J., and Walker, D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Pest Management Science
ISSN (Online):1526-4998
Published Online:02 February 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Pest Management Science 2021
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
190773A novel mechanism of protein uptake in Gram-negative bacteriaDaniel WalkerBiotechnology and Biological Sciences Research Council (BBSRC)BB/L02022X/1III - Bacteriology
307270Exploiting bacteriocins for plant protection against pathogenic bacteriaJoel MilnerBiotechnology and Biological Sciences Research Council (BBSRC)BB/T004207/1III - Bacteriology
173241Protein Antibiotics: Discovery, mode of action and developmentDaniel WalkerWellcome Trust (WELLCOTR)ALR01040 / 201505/Z/16/ZIII - Bacteriology