You talking to me? Cadherin and integrin crosstalk in biomaterials design

Barcelona Estaje, E., Dalby, M. J. , Cantini, M. and Salmeron-Sanchez, M. (2021) You talking to me? Cadherin and integrin crosstalk in biomaterials design. Advanced Healthcare Materials, 10(6), 2002048. (doi: 10.1002/adhm.202002048) (PMID:33586353)

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While much work has been done in the design of biomaterials to control integrin‐mediated adhesion, less emphasis has been put on functionalization of materials with cadherin ligands. Yet, cell–cell contacts in combination with cell–matrix interactions are key in driving embryonic development, collective cell migration, epithelial to mesenchymal transition, and cancer metastatic processes, among others. This review focuses on the incorporation of both cadherin and integrin ligands in biomaterial design, to promote what is called the “adhesive crosstalk.” First, the structure and function of cadherins and their role in eliciting mechanotransductive processes, by themselves or in combination with integrin mechanosensing, are introduced. Then, biomaterials that mimic cell–cell interactions, and recent applications to get insights in fundamental biology and tissue engineering, are critically discussed.

Item Type:Articles
Additional Information:This work was supported by an EPSRC Programme Grant (No. EP/P001114/1). The authors acknowledge support from a grant from the UK Regenerative Medicine Platform “Acellular/Smart Materials – 3D Architecture” (Grant No. MR/R015651/1) and MRC funding (Grant No. MR/S005412/1).
Glasgow Author(s) Enlighten ID:Barcelona Estaje, Dr Eva and Salmeron-Sanchez, Professor Manuel and Dalby, Professor Matthew and Cantini, Dr Marco
Authors: Barcelona Estaje, E., Dalby, M. J., Cantini, M., and Salmeron-Sanchez, M.
College/School:College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
College of Science and Engineering > School of Engineering
College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Advanced Healthcare Materials
ISSN (Online):2192-2659
Published Online:15 February 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Advanced Healthcare Materials 10(6):2002048
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
173192Engineering growth factor microenvironments- a new therapeutic paradigm for regenerative medicineManuel Salmeron-SanchezEngineering and Physical Sciences Research Council (EPSRC)EP/P001114/1ENG - Biomedical Engineering
301095UKRMP2 Acellular/Smart Materials 3D Architecture HubManuel Salmeron-SanchezMedical Research Council (MRC)MMRE_P75176 (MR/R015651/1ENG - Biomedical Engineering
303613Engineered microenvironments to harvest stem cell response to viscosity for cartilage repairMarco CantiniMedical Research Council (MRC)MR/S005412/1ENG - Biomedical Engineering