The association between C-reactive protein, mood disorder and cognitive function in UK Biobank European Psychiatry

Milton, D. C., Ward, J. , Ward, E., Lyall, D. M. , Strawbridge, R. J. , Smith, D. J. and Cullen, B. (2021) The association between C-reactive protein, mood disorder and cognitive function in UK Biobank European Psychiatry. European Psychiatry, 64(1), e14. (doi: 10.1192/j.eurpsy.2021.6) (PMID:33517931) (PMCID:PMC8057439)

[img] Text
232663.pdf - Published Version
Available under License Creative Commons Attribution.



Background: Systemic inflammation has been linked with mood disorder and cognitive impairment. The extent of this relationship remains uncertain, with the effects of serum inflammatory biomarkers compared to genetic predisposition toward inflammation yet to be clearly established. Methods: We investigated the magnitude of associations between C-reactive protein (CRP) measures, lifetime history of bipolar disorder or major depression, and cognitive function (reaction time and visuospatial memory) in 84,268 UK Biobank participants. CRP was measured in serum and a polygenic risk score for CRP was calculated, based on a published genome-wide association study. Multiple regression models adjusted for sociodemographic and clinical confounders. Results: Increased serum CRP was significantly associated with mood disorder history (Kruskal–Wallis H = 196.06, p < 0.001, η2 = 0.002) but increased polygenic risk for CRP was not (F = 0.668, p = 0.648, η2 < 0.001). Compared to the lowest quintile, the highest serum CRP quintile was significantly associated with both negative and positive differences in cognitive performance (fully adjusted models: reaction time B = −0.030, 95% CI = −0.052, −0.008; visuospatial memory B = 0.066, 95% CI = 0.042, 0.089). More severe mood disorder categories were significantly associated with worse cognitive performance and this was not moderated by serum or genetic CRP level. Conclusions: In this large cohort study, we found that measured inflammation was associated with mood disorder history, but genetic predisposition to inflammation was not. The association between mood disorder and worse cognitive performance was very small and did not vary by CRP level. The inconsistent relationship between CRP measures and cognitive performance warrants further study.

Item Type:Articles
Additional Information:R.J.S. is supported by a UKRI Innovation-HDR-UK Fellowship (MR/S003061/1). D.J.S. acknowledges support from a Lister Institute Prize Fellowship and an MRC Mental Health Data Pathfinder Award (MC_PC_17217). J.W. is supported by D.J.S.’s Lister Institute Prize Fellowship.
Glasgow Author(s) Enlighten ID:Smith, Professor Daniel and Cullen, Dr Breda and Ward, Dr Joey and Strawbridge, Dr Rona and Lyall, Dr Donald
Authors: Milton, D. C., Ward, J., Ward, E., Lyall, D. M., Strawbridge, R. J., Smith, D. J., and Cullen, B.
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Mental Health and Wellbeing
College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health
Journal Name:European Psychiatry
Publisher:Cambridge University Press
ISSN (Online):1778-3585
Published Online:01 February 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in European Psychiatry 64(1):e14
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record

Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
302131Understanding the excess risk of cardiometabolic disease in individuals with serious mental illnessJill PellMedical Research Council (MRC)MR/S003061/1HW - Public Health
302957Mental Health Data PathfinderDaniel SmithMedical Research Council (MRC)MC_PC_17217HW - Mental Health and Wellbeing