Insights into the molecular profiles of adult and paediatric acute myeloid leukaemia

Aung, M. M. K., Mills, M. L., Bittencourt-Silvestre, J. and Keeshan, K. (2021) Insights into the molecular profiles of adult and paediatric acute myeloid leukaemia. Molecular Oncology, 15(9), pp. 2253-2272. (doi: 10.1002/1878-0261.12899) (PMID:33421304) (PMCID:PMC8410545)

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Acute Myeloid Leukaemia (AML) is a clinically and molecularly heterogeneous disease characterised by uncontrolled proliferation, block in differentiation and acquired self-renewal of hematopoietic stem and myeloid progenitor cells. This results in the clonal expansion of myeloid blasts within the bone marrow and peripheral blood. The incidence of AML increases with age, and in childhood, AML accounts for 20% of all leukaemias. Whilst there are many clinical and biological similarities between paediatric and adult AML with continuum across the age range, many characteristics of AML are associated with age of disease onset. These include chromosomal aberrations, gene mutations, and differentiation lineage. Following chemotherapy, AML cells that survive and result in disease relapse, exist in an altered chemoresistant state. Molecular profiling currently represents a powerful avenue of experimentation to study AML cells from adults and children pre-and post-chemotherapy as a means of identifying prognostic biomarkers and targetable molecular vulnerabilities that may be age-specific. This review highlights recent advances in our knowledge of the molecular profiles with a focus on transcriptomes and metabolomes, leukaemia stem cells and chemoresistant cells in adult and paediatric AML, and focus on areas that hold promise for future therapies.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Silvestre, Ms Joana and Keeshan, Dr Karen
Authors: Aung, M. M. K., Mills, M. L., Bittencourt-Silvestre, J., and Keeshan, K.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Molecular Oncology
ISSN (Online):1878-0261
Published Online:09 January 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Molecular Oncology 15(9): 2253-2272
Publisher Policy:Reproduced under a Creative Commons License

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