Breton, É., Légaré, C., Overend, G. , Guay, S.-P., Monckton, D. , Mathieu, J., Gagnon, C., Richer, L., Gallais, B. and Bouchard, L. (2020) DNA methylation at the DMPK gene locus is associated with cognitive functions in myotonic dystrophy type 1. Epigenomics, 12(23), pp. 2051-2064. (doi: 10.2217/epi-2020-0328) (PMID:33301350)
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Abstract
Aim: Myotonic dystrophy type 1 (DM1) is caused by an unstable trinucleotide (CTG) expansion at the DMPK gene locus. Cognitive dysfunctions are often observed in the condition. We investigated the association between DMPK blood DNA methylation (DNAm) and cognitive functions in DM1, considering expansion length and variant repeats (VRs). Method: Data were obtained from 115 adult-onset DM1 patients. Molecular analyses consisted of pyrosequencing, small pool PCR and Southern blot hybridization. Cognitive functions were assessed by validated neuropsychological tests. Results: For patients without VRs (n = 103), blood DNAm at baseline independently contributed to predict cognitive functions 9 years later. Patients with VRs (n = 12) had different DNAm and cognitive profiles. Conclusion: DNAm allows to better understand DM1-related cognitive dysfunction etiology.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Overend, Dr Gayle and Monckton, Professor Darren |
| Authors: | Breton, É., Légaré, C., Overend, G., Guay, S.-P., Monckton, D., Mathieu, J., Gagnon, C., Richer, L., Gallais, B., and Bouchard, L. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
| Journal Name: | Epigenomics |
| Publisher: | Future Medicine Ltd. |
| ISSN: | 1750-1911 |
| ISSN (Online): | 1750-192X |
| Published Online: | 10 December 2020 |
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