D-dimer predicts early clinical progression in ischemic stroke: confirmation using routine clinical assays

Barber, M., Langhorne, P. , Rumley, A., Lowe, G.D.O. and Stott, D.J. (2006) D-dimer predicts early clinical progression in ischemic stroke: confirmation using routine clinical assays. Stroke, 37(4), pp. 1113-1115. (doi: 10.1161/01.STR.0000209240.63821.1a)

Abstract

<p><b>Background and Purpose:</b> Plasma D-dimer levels, measured using a research laboratory assay, independently predict progressing ischemic stroke. We wished to confirm these findings using commercially available assays and to provide data to allow the design of intervention studies.</p> <p><b>Methods:</b> We studied 219 consecutive acute ischemic stroke admissions of whom 54 (25%) met criteria for progressing stroke.</p> <p><b>Results:</b> There were strong correlations between D-dimer results as measured by the Biopool AB, MDA and VIDAS assays; correlation coefficients r=0.91 to 0.94; all P<0.001. In binary logistic regression analyses, D-dimer, as measured by the 3 different assays, was an independent predictor of progressing stroke (odds ratios, 1.87 to 2.45; all P<0.001). This confirms the results of our original analysis (Biopool AB) using 2 commercial D-dimer assays, demonstrating the potential usefulness of D-dimer in providing early prognostic information after ischemic stroke in different clinical settings. We also provide information on the performance of the 3 assays in predicting progressing stroke at a variety of cutoff values.</p> <p><b>Conclusions:</b> Ischemic stroke patients at high risk of early progression can be identified using commercial D-dimer measurements. This could allow selection of high-risk patients for inclusion in randomized trials of early antithrombotic treatments.</p>

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Stott J, Professor David and Rumley, Dr Ann and Langhorne, Professor Peter and Lowe, Professor Gordon
• Authors: Barber, M., Langhorne, P., Rumley, A., Lowe, G.D.O., and Stott, D.J.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Stroke
• Publisher: American Heart Association
• ISSN: 0039-2499
• ISSN (Online): 1524-4628
• Published Online: 09 March 2006
• Copyright Holders: Copyright © 2006 American Heart Association
• First Published: First published in Stroke 37(4):1113-1115
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher