Endothelial activation and cell adhesion molecule concentrations in pregnant women living at high altitude

Marks, L., Zarnudio, S., Cousins, F., Duffie, E. and Lyall, F. (2006) Endothelial activation and cell adhesion molecule concentrations in pregnant women living at high altitude. Journal of the Society For Gynecologic Investigation, 13(6), pp. 399-403. (doi: 10.1016/j.jsgi.2006.05.001) (PMID:16879990)

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Abstract

Objectives:Maternal physiology at high altitude could be considered to resemble an intermediate state between preeclampsia and normal pregnancy. The objective of the current study was to determine if cell adhesion molecules, known to be increased in preeclampsia, are increased with chronic maternal and placental hypoxia (due to high-altitude residence) in the absence of preeclampsia. Methods:Serum was collected from women residing at 3100 m or 1600 m in the three trimesters of pregnancy and postpartum. Vascular cell adhesion molecule-1 (VCAM-1), E-selectin, and intercellular adhesion molecule-1 (ICAM-1) were measured by enzyme-linked immunosorbent assay (ELISA). Results:General linear model (GLM) repeated measures analysis of VCAM-1, E-selectin, and ICAM-1 data showed there were no statistically signiciant effects of gestation within either the high- or moderate-altitude groups or between the different altitude. Conclusion:The increase in cell adhesion molecules reported in preeclampsia is not present in pregnant women at high altitude, suggesting that maternal systemic hypoxia is not responsible for this pathway of endothelial cell activation in preeclampsia.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cousins, Mrs Frances and Duffie, Mrs Elizabeth and Marks, Dr Leah and Lyall, Professor Fiona
Authors: Marks, L., Zarnudio, S., Cousins, F., Duffie, E., and Lyall, F.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Journal of the Society For Gynecologic Investigation
Publisher:Elsevier Inc.
ISSN:1071-5576
ISSN (Online):1556-7117

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