Bioengineering case study to evaluate complications of adverse anatomy of aortic root in transcatheter aortic valve replacement: combining biomechanical modelling with CT imaging

Spadaccio, C., Mazzocchi, L., Timofeva, I., Macron, L., De Cecco, C. N., Morganti, S., Auricchio, F. and Nappi, F. (2020) Bioengineering case study to evaluate complications of adverse anatomy of aortic root in transcatheter aortic valve replacement: combining biomechanical modelling with CT imaging. Bioengineering, 7(4), 121. (doi: 10.3390/bioengineering7040121) (PMID:33019739) (PMCID:PMC7712517)

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Abstract

Gated computed tomography (CT) might not adequately predict occurrence of post-implantation transcatheter aortic valve replacement (TAVR) complications in hostile aortic root as it would require a more complex integration of morphological, functional and hemodynamical parameters. We used a computational framework based on finite element analysis (FEA) to simulate patient-specific implantation. Application of biomechanical modelling using FEA to gated-CT was able to demonstrate the relation of the device with voluminous calcification, its consequent misalignment and a significant stent deformation. Use of FEA and other advanced computed predictive modelling techniques as an adjunct to CT scan could improve our understanding of TAVR, potentially predict complications and fate of the devices after implantation and inform patient-specific treatment.

Item Type:Articles
Keywords:Biomechanical modelling, calcification, complications, finite element analysis (FEA), transcatheter aortic valve replacement (TAVR).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Spadaccio, Dr Cristiano
Creator Roles:
Spadaccio, C.Formal analysis, Writing – original draft, Writing – review and editing
Authors: Spadaccio, C., Mazzocchi, L., Timofeva, I., Macron, L., De Cecco, C. N., Morganti, S., Auricchio, F., and Nappi, F.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Bioengineering
Publisher:MDPI
ISSN:2306-5354
ISSN (Online):2306-5354
Published Online:01 October 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Bioengineering 7(4): 121
Publisher Policy:Reproduced under a Creative Commons License

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