COllaborative Neuropathology NEtwork Characterizing ouTcomes of TBI (CONNECT-TBI)

Smith, D. H. et al. (2021) COllaborative Neuropathology NEtwork Characterizing ouTcomes of TBI (CONNECT-TBI). Acta Neuropathologica Communications, 9, 32. (doi: 10.1186/s40478-021-01122-9) (PMID:33648593) (PMCID:PMC7919306)

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Efforts to characterize the late effects of traumatic brain injury (TBI) have been in progress for some time. In recent years much of this activity has been directed towards reporting of chronic traumatic encephalopathy (CTE) in former contact sports athletes and others exposed to repetitive head impacts. However, the association between TBI and dementia risk has long been acknowledged outside of contact sports. Further, growing experience suggests a complex of neurodegenerative pathologies in those surviving TBI, which extends beyond CTE. Nevertheless, despite extensive research, we have scant knowledge of the mechanisms underlying TBI-related neurodegeneration (TReND) and its link to dementia. In part, this is due to the limited number of human brain samples linked to robust demographic and clinical information available for research. Here we detail a National Institutes for Neurological Disease and Stroke Center Without Walls project, the COllaborative Neuropathology NEtwork Characterizing ouTcomes of TBI (CONNECT-TBI), designed to address current limitations in tissue and research access and to advance understanding of the neuropathologies of TReND. As an international, multidisciplinary collaboration CONNECT-TBI brings together multiple experts across 13 institutions. In so doing, CONNECT-TBI unites the existing, comprehensive clinical and neuropathological datasets of multiple established research brain archives in TBI, with survivals ranging minutes to many decades and spanning diverse injury exposures. These existing tissue specimens will be supplemented by prospective brain banking and contribute to a centralized route of access to human tissue for research for investigators. Importantly, each new case will be subject to consensus neuropathology review by the CONNECT-TBI Expert Pathology Group. Herein we set out the CONNECT-TBI program structure and aims and, by way of an illustrative case, the approach to consensus evaluation of new case donations.

Item Type:Articles
Additional Information:Funding provided to the CWOW CONNECT-TBI group was from the U.S. National Institutes of Health, National Institute of Neurologic Disorders and Stroke (Grant # NS115322: D.H.S, W.S).
Glasgow Author(s) Enlighten ID:McCabe, Dr Thomas and Stewart, Dr William and Ameen-Ali, Dr Kamar
Authors: Smith, D. H., Dollé, J.-P., Ameen-Ali, K. E., Bretzin, A., Cortes, E., Crary, J. F., Dams-O'Connor, K., Diaz-Arrastia, R., Edlow, B. L., Folkerth, R., Hazrati, L.-N., Hinds, S. R., Iacono, D., Johnson, V. E., Keene, C. D., Kofler, J., Kovacs, G. G., Lee, E. B., Manley, G., Meaney, D., Montine, T., Okonkwo, D. O., Perl, D. P., Trojanowski, J. Q., Wiebe, D. J., Yaffe, K., McCabe, T., and Stewart, W.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Acta Neuropathologica Communications
ISSN (Online):2051-5960
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Acta Neuropathologica Communications 9:32
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
307485COllaborative Neuropathology NEtwork Characterizing ouTcomes of TBIWilliam StewartNational Institutes of Health (NIH)u54ns115322Institute of Neuroscience & Psychology