González-Cabaleiro, R. , Martinez-Rabert, E. , Argiz, L., van Kessel, M. A.H.J. and Smith, C. J. (2021) A framework based on fundamental biochemical principles to engineer microbial community dynamics. Current Opinion in Biotechnology, 67, pp. 111-118. (doi: 10.1016/j.copbio.2021.01.001) (PMID:33540361)
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Abstract
Microbial communities are complex but there are basic principles we can apply to constrain the assumed stochasticity of their activity. By understanding the trade-offs behind the kinetic parameters that define microbial growth, we can explain how local interspecies dependencies arise and shape the emerging properties of a community. If we integrate these theoretical descriptions with experimental ‘omics’ data and bioenergetics analysis of specific environmental conditions, predictions on activity, assembly and spatial structure can be obtained reducing the a priori unpredictable complexity of microbial communities. This information can be used to define the appropriate selective pressures to engineer bioprocesses and propose new hypotheses which can drive experimental research to accelerate innovation in biotechnology.
Item Type: | Articles |
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Additional Information: | The authors thank the support of the Frontier Engineering grant “Synthetic biology applications to water supply and remediation” (EP/K038885/1), the University of Glasgow James Watt EPSRC Scholarship (EP/R513222/1), and the Xunta de Galicia Fellowship (ED481A-2019/ 083). Cindy J. Smith is supported by Royal Academy of Engineering-Scottish Water Research Chair (RCSRF1718643). |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Gonzalez-Cabaleiro, Dr Rebeca and Argiz, Lucia and Martínez Rabert, Eloy and Smith, Professor Cindy |
Authors: | González-Cabaleiro, R., Martinez-Rabert, E., Argiz, L., van Kessel, M. A.H.J., and Smith, C. J. |
College/School: | College of Science and Engineering > School of Engineering > Infrastructure and Environment |
Journal Name: | Current Opinion in Biotechnology |
Publisher: | Elsevier |
ISSN: | 0958-1669 |
ISSN (Online): | 1879-0429 |
Published Online: | 01 February 2021 |
Copyright Holders: | Copyright © 2021 Elsevier |
First Published: | First published in Current Opinion in Biotechnology 67:111-118 |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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