Image‐based computational fluid dynamics for estimating pressure drop and fractional flow reserve across iliac artery stenosis: a comparison with in‐vivo measurements

Skopalik, S., Hall Barrientos, P., Matthews, J., Radjenovic, A. , Mark, P. , Roditi, G. and Paul, M. C. (2021) Image‐based computational fluid dynamics for estimating pressure drop and fractional flow reserve across iliac artery stenosis: a comparison with in‐vivo measurements. International Journal for Numerical Methods in Biomedical Engineering, 37(12), e3437. (doi: 10.1002/cnm.3437) (PMID:33449429)

Abstract

Computational Fluid Dynamics (CFD) and time‐resolved phase‐contrast magnetic resonance imaging (PC‐MRI) are potential non‐invasive methods for the assessment of the severity of arterial stenoses. Fractional flow reserve (FFR) is the current “gold standard” for determining stenosis severity in the coronary arteries but is an invasive method requiring insertion of a pressure wire. CFD derived FFR (vFFR) is an alternative to traditional catheter derived FFR now available commercially for coronary artery assessment, however, it can potentially be applied to a wider range of vulnerable vessels such as the iliac arteries. In this study CFD simulations are used to assess the ability of vFFR in predicting the stenosis severity in a patient with a stenosis of 77% area reduction (>50% diameter reduction) in the right iliac artery. Variations of vFFR, overall pressure drop and flow split between the vessels were observed by using different boundary conditions. Correlations between boundary condition parameters and resulting flow variables are presented. The study concludes that vFFR has good potential to characterise iliac artery stenotic disease.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Skopalik, Dr Simeon and Paul, Professor Manosh and Roditi, Dr Giles and Mark, Professor Patrick and Hall Barrientos, Dr Pauline and Radjenovic, Dr Aleksandra
• Authors: Skopalik, S., Hall Barrientos, P., Matthews, J., Radjenovic, A., Mark, P., Roditi, G., and Paul, M. C.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing; College of Science and Engineering > School of Engineering; College of Science and Engineering > School of Engineering > Systems Power and Energy
• Journal Name: International Journal for Numerical Methods in Biomedical Engineering
• Publisher: Wiley
• ISSN: 2040-7939
• ISSN (Online): 2040-7947
• Published Online: 15 January 2021
• Copyright Holders: Copyright © 2021 The Authors
• First Published: First published in International Journal for Numerical Methods in Biomedical Engineering 37(12): e3437
• Publisher Policy: Reproduced under a Creative Commons License