Family history of diabetes and risk of SARS-COV-2 in UK Biobank: a prospective cohort study

Jani, B. D. et al. (2021) Family history of diabetes and risk of SARS-COV-2 in UK Biobank: a prospective cohort study. Endocrinology, Diabetes and Metabolism, 4(4), e00283. (doi: 10.1002/edm2.283) (PMID:34505416) (PMCID:PMC8420405)

Abstract

Introduction: The aim of this study was to determine risk of being SARS-CoV-2 positive and severe infection (associated with hospitalization/mortality) in those with family history of diabetes. Methods: We used UK Biobank, an observational cohort recruited between 2006 and 2010. We compared the risk of being SARS-CoV-2 positive and severe infection for those with family history of diabetes (mother/father/sibling) against those without. Results: Of 401,268 participants in total, 13,331 tested positive for SARS-CoV-2 and 2282 had severe infection by end of January 2021. In unadjusted models, participants with ≥2 family members with diabetes were more likely to be SARS-CoV-2 positive (risk ratio-RR 1.35; 95% confidence interval-CI 1.24–1.47) and severe infection (RR 1.30; 95% CI 1.04–1.59), compared to those without. The excess risk of being tested positive for SARS-CoV-2 was attenuated but significant after adjusting for demographics, lifestyle factors, multimorbidity and presence of cardiometabolic conditions. The excess risk for severe infection was no longer significant after adjusting for demographics, lifestyle factors, multimorbidity and presence of cardiometabolic conditions, and was absent when excluding incident diabetes. Conclusion: The totality of the results suggests that good lifestyle and not developing incident diabetes may lessen risks of severe infections in people with a strong family of diabetes.

• Item Type: Articles
• Keywords: Diabetes, family history, lifestyle, SARS-CoV-2.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Hastie, Dr Claire and Ho, Dr Frederick and Gill, Professor Jason and Anderson, Dr Jana and Foster, Dr Hamish and Nicholl, Dr Barbara and Jani, Dr Bhautesh and Welsh, Professor Paul and Bailey, Dr Mark and Mair, Professor Frances and Celis, Dr Carlos and Gray, Professor Stuart and Pell, Professor Jill and Hanlon, Dr Peter and Sattar, Professor Naveed and Lyall, Dr Donald
• Authors: Jani, B. D., Nicholl, B. I., Hanlon, P., Mair, F. S., Gill, J. M.R., Gray, S. R., Celis-Morales, C. A., Ho, F. K., Lyall, D. M., Anderson, J. J., Hastie, C. E., Bailey, M. E.S., Foster, H., Pell, J. P., Welsh, P., and Sattar, N.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > General Practice and Primary Care; College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health; College of Medical Veterinary and Life Sciences > School of Life Sciences; College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
• Journal Name: Endocrinology, Diabetes and Metabolism
• Publisher: Wiley
• ISSN: 2398-9238
• ISSN (Online): 2398-9238
• Published Online: 11 July 2021
• Copyright Holders: Copyright © 2021 The Authors
• First Published: First published in Endocrinology, Diabetes and Metabolism 4(4): e00283
• Publisher Policy: Reproduced under a Creative Commons License

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
303944		BHF Centre of Excellence	Rhian Touyz	British Heart Foundation (BHF)	RE/18/6/34217	CAMS - Cardiovascular Science