Waldenstrom's macroglobulinaemia secreting a paraprotein with lupus anticoagulant activity: possible association with gastrointestinal tract disease and malabsorption

Tait, R.C. , Oogarah, P.K., Houghton, J.B., Farrand, S.E. and Haeney, M.R. (1993) Waldenstrom's macroglobulinaemia secreting a paraprotein with lupus anticoagulant activity: possible association with gastrointestinal tract disease and malabsorption. Journal of Clinical Pathology, 46(7), pp. 678-680. (doi: 10.1136/jcp.46.7.678) (PMID:8157762) (PMCID:PMC501404)

Full text not currently available from Enlighten.

Abstract

A 51 year old man with Waldenström's macroglobulinaemia presented with a malabsorptive syndrome related to extensive small bowel lymphangiectasia caused by immunoglobulin accumulation. The patient's plasma had strong lupus anticoagulant activity and the IgM lambda paraprotein displayed specificity for the negatively charged phospholipids phosphatidyl serine and phosphatidyl inositol, as well as the neutral phosphatidic acid. Despite treatment for the macroglobulinaemia the patient died and at necropsy was found to have myocardial ischaemia and segmental infarcts in the spleen and kidney. The coexistence of these relatively rare findings suggests a possible association between Waldenström's macroglobulinaemia with gastrointestinal manifestations and paraprotein specificity for phospholipid.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Tait, Dr Robert
Authors: Tait, R.C., Oogarah, P.K., Houghton, J.B., Farrand, S.E., and Haeney, M.R.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Journal of Clinical Pathology
Publisher:BMJ Publishing Group
ISSN:0021-9746
ISSN (Online):1472-4146

University Staff: Request a correction | Enlighten Editors: Update this record