Development of resistance to activated protein C during pregnancy

Cumming, A.M., Tait, R.C. , Fildes, S., Yoong, A., Keeney, S. and Hay, C.R.M. (1995) Development of resistance to activated protein C during pregnancy. British Journal of Haematology, 90(3), pp. 725-727. (doi: 10.1111/j.1365-2141.1995.tb05610.x) (PMID:7647019)

Abstract

We measured activated protein C (APC) anticoagulant activity in 20 healthy women at 14‐20, 28 and 36 weeks gestation, and at 1 d post‐partum. Significant reductions in the mean APC sensitivity ratio (APC‐SR) were observed at all stages of pregnancy studied compared with the mean APC‐SR obtained for baseline measurements carried out at > 8 weeks post‐partum. APC resistance was seen in 8/19 (42%) and in 11/20 (55%) women at 14‐20 and 28 weeks gestation respectively. The development of resistance to APC may contribute to the increased risk of thrombosis during pregnancy.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Tait, Dr Robert
• Authors: Cumming, A.M., Tait, R.C., Fildes, S., Yoong, A., Keeney, S., and Hay, C.R.M.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: British Journal of Haematology
• Publisher: Blackwell Science
• ISSN: 0007-1048
• ISSN (Online): 1365-2141