Superficial vein thrombosis: incidence in association with pregnancy and prevalence of thrombophilic defects

McColl, M.D., Ramsay, J.E., Tait, R.C. , Walker, I.D., McCall, F., Conkie, J.A., Carty, M.J. and Greer, I.A. (1998) Superficial vein thrombosis: incidence in association with pregnancy and prevalence of thrombophilic defects. Thrombosis and Haemostasis, 79(4), pp. 741-742. (doi: 10.1055/s-0037-1615056) (PMID:9569184)

Abstract

Superficial venous thrombotic (SVT) events are a feature of thrombophilic abnormalities, particularly those involving the protein C pathway. We have determined the incidence of SVT associated with pregnancy and the early postpartum period in a retrospective study involving 72 000 deliveries. Fourty-nine cases occurring in 47 individuals were recorded, with an overall incidence of 0.68/1000 deliveries (95% CI 0.48-0.88). None had a previous history of deep vein thrombosis or pulmonary embolism. Most events occurred in the early post-partum period (0.54/1000 deliveries). Twenty-four/fourty-seven were screened for established thrombophilic abnormalities, with only 1 abnormality detected (FVLeiden heterozygote). Thrombophilia may play a minor role in the aetiology of SVT associated with pregnancy, although a larger study is required to confirm this.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Walker, Prof Isobel and Ramsay, Dr Jane and Tait, Dr Robert and McColl, Dr Mark
• Authors: McColl, M.D., Ramsay, J.E., Tait, R.C., Walker, I.D., McCall, F., Conkie, J.A., Carty, M.J., and Greer, I.A.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Thrombosis and Haemostasis
• Publisher: Georg Thieme
• ISSN: 0340-6245
• ISSN (Online): 2567-689X