Nausea and vomiting in people with cancer and other chronic diseases

Keeley, P. (2009) Nausea and vomiting in people with cancer and other chronic diseases. BMJ Clinical Evidence, 1(2406), (PMID:19445763) (PMCID:PMC2907825)

Abstract

Introduction Nausea and vomiting occur in 40%–70% of people with cancer, and are also common in other chronic conditions such as hepatitis C and inflammatory bowel disease. Nausea and vomiting become more common as disease progresses. Methods and outcomes We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of treatments for nausea and vomiting occurring as a result of either the disease or its treatment in adults with cancer? What are the effects of treatments for nausea and vomiting occurring as a result of either the disease or its treatment in adults with chronic diseases other than cancer? We searched: Medline, Embase, The Cochrane Library, and other important databases up to April 2008 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). Results We found nine systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. Conclusions In this systematic review we present information relating to the effectiveness and safety of the following interventions: 5HT3 antagonists, antihistamines, antimuscarinics, atypical antipsychotics, benzodiazepines, butyrophenones, cannabinoids, corticosteroids, haloperidol, metoclopramide, NK1 antagonists, phenothiazines, prokinetics, 5HT3 antagonists plus corticosteroids, and venting gastrostomy.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Keeley, Dr Paul
• Authors: Keeley, P.
• Subjects: R Medicine > R Medicine (General)
• College/School: College of Medical Veterinary and Life Sciences
• Journal Name: BMJ Clinical Evidence
• Publisher: BMJ