Engineered diets to improve cancer outcomes

Goncalves, M. D. and Maddocks, O. D.K. (2021) Engineered diets to improve cancer outcomes. Current Opinion in Biotechnology, 70, pp. 29-35. (doi: 10.1016/j.copbio.2020.10.007) (PMID:33232844)

Abstract

Cancer cells acquire a diverse range of metabolic adaptations that support their enhanced rates of growth and proliferation. While these adaptations help tune metabolism to support higher anabolic output and bolster antioxidant defenses, they can also decrease metabolic flexibility and increase dependence on nutrient uptake versus de novo synthesis. Diet is the major source of nutrients that ultimately support tumor growth, yet the potential impact of diet is currently underutilized during the treatment of cancer. Here, we review several forms of dietary augmentation therapy including those that alter the content of food, such as energy or macronutrient restriction, and those that alter the timing of food consumption, like intermittent fasting regimens. We discuss how these dietary strategies can be combined with pharmacologic therapies to exaggerate the metabolic liabilities of different cancer types.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Maddocks, Professor Oliver
• Authors: Goncalves, M. D., and Maddocks, O. D.K.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Current Opinion in Biotechnology
• Publisher: Elsevier
• ISSN: 0958-1669
• ISSN (Online): 1879-0429
• Published Online: 21 November 2020
• Copyright Holders: Copyright © 2020 Elsevier Ltd.
• First Published: First published in Current Opinion in Biotechnology 70:29-35
• Publisher Policy: Reproduced in accordance with the publisher copyright policy

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
171982		Targeting Tumour Metabolism for Cancer Therapy and Diagnosis.	Oliver Maddocks	Cancer Research UK (CRUK)	C53309/A19702	Institute of Cancer Sciences