Bonilha, C. S., Benson, R. A. , Brewer, J. M. and Garside, P. (2020) Targeting opposing immunological roles of the junctional adhesion molecule-A in autoimmunity and cancer. Frontiers in Immunology, 11, 602094. (doi: 10.3389/fimmu.2020.602094) (PMID:33324419) (PMCID:PMC7723963)
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Abstract
The junctional adhesion molecule-A (JAM-A) is a cell surface adhesion molecule expressed on platelets, epithelial cells, endothelial cells and leukocytes (e. g. monocytes and dendritic cells). JAM-A plays a relevant role in leukocyte trafficking and its therapeutic potential has been studied in several pathological conditions due to its capacity to induce leukocyte migration out of inflamed sites or infiltration into tumor sites. However, disruption of JAM-A pathways may worsen clinical pathology in some cases. As such, the effects of JAM-A manipulation on modulating immune responses in the context of different diseases must be better understood. In this mini-review, we discuss the potential of JAM-A as a therapeutic target, summarizing findings from studies manipulating JAM-A in the context of inflammatory diseases (e.g. autoimmune diseases) and cancer and highlighting described mechanisms.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Benson, Dr Robert and Garside, Professor Paul and Brewer, Professor James and Bonilha, Mr Caio |
Authors: | Bonilha, C. S., Benson, R. A., Brewer, J. M., and Garside, P. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Research Centre: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology |
Journal Name: | Frontiers in Immunology |
Publisher: | Frontiers Media |
ISSN: | 1664-3224 |
ISSN (Online): | 1664-3224 |
Copyright Holders: | Copyright © 2020 Bonilha, Benson, Brewer and Garside |
First Published: | First published in Frontiers in Immunology 11:602094 |
Publisher Policy: | Reproduced under a Creative Commons licence |
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