Barber, M.D., McMillan, D.C., Wallace, A.M., Ross, J.A., Preston, T. and Fearon, K.C.H. (2004) The response of leptin, interleukin-6 and fat oxidation to feeding in weight-losing patients with pancreatic cancer. British Journal of Cancer, 90(6), 1129 -1132. (doi: 10.1038/sj.bjc.6601712)
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Publisher's URL: http://dx.doi.org/10.1038/sj.bjc.6601712
Abstract
At baseline, weight-losing pancreatic cancer patients (n=7) had lower leptin (P<0.05) but higher cortisol, interleukin-6, resting energy expenditure and fat oxidation than healthy subjects (n=6, P<0.05). Over a 4 h feeding period, the areas under the curve for glucose, cortisol and interleukin-6 were greater (P<0.05), but less for leptin in the cancer group (P<0.05). Therefore, it would appear that low leptin concentrations, increased fat oxidation and insulin resistance are associated with increased concentrations of cortisol and interleukin-6 in weight-losing patients with pancreatic cancer.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Fearon, Prof Kenneth and Preston, Professor Tom |
Authors: | Barber, M.D., McMillan, D.C., Wallace, A.M., Ross, J.A., Preston, T., and Fearon, K.C.H. |
Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
College/School: | College of Science and Engineering > Scottish Universities Environmental Research Centre |
Journal Name: | British Journal of Cancer |
ISSN: | 0007-0920 |
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