Vartiainen, M. K. and Machesky, L. M. (2004) The WASP–Arp2/3 pathway: genetic insights. Current Opinion in Cell Biology, 16(2), pp. 174-181. (doi: 10.1016/j.ceb.2004.02.004) (PMID:15196561)
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Abstract
Arp2/3 complex nucleates the formation of dendritic actin filament arrays, which are especially prominent at the leading edges of motile cells. Recent genetic and other loss-of-function studies have highlighted the importance of the Arp2/3 complex for normal cell functions, and especially for cell motility. WASP/Scar family proteins regulate the activity of the Arp2/3 complex, and also link it to several signaling pathways. Recent studies suggest that Scar is a more important regulator of Arp2/3 activity in actin-dependent morphological processes than WASP, which may have a more restricted role in specialized cellular events. It has also become clear that precise regulation of both Scar and WASP activity is of the utmost importance for their physiological functions.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Machesky, Professor Laura |
| Authors: | Vartiainen, M. K., and Machesky, L. M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Current Opinion in Cell Biology |
| Publisher: | Elsevier |
| ISSN: | 0955-0674 |
| ISSN (Online): | 1879-0410 |
| Published Online: | 25 February 2004 |
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