Inclusion of Scar/WAVE3 in a similar complex to Scar/WAVE1 and 2

Stovold, C. F., Millard, T. H. and Machesky, L. M. (2005) Inclusion of Scar/WAVE3 in a similar complex to Scar/WAVE1 and 2. BMC Cell Biology, 6, 11. (doi: 10.1186/1471-2121-6-11) (PMID:15752430) (PMCID:PMC555569)

Abstract

Background: The Scar/WAVE family of proteins mediates signals to actin assembly by direct activation of the Arp2/3 complex. These proteins have been characterised as major regulators of lamellipodia formation downstream of Rac activation and as members of large protein complexes. Results: We have investigated the interactions of the three human Scar/WAVE isoforms with several previously described binding partners for Scar/WAVE 1 or 2. We find that all three Scar/ WAVE isoforms behave similarly and are likely to participate in the same kinds of protein complexes that regulate actin assembly. Conclusion: Differences between Scar/WAVE proteins are therefore likely to be at the level of tissue distribution or subtle differences in the affinity for specific binding partners.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Machesky, Professor Laura
• Authors: Stovold, C. F., Millard, T. H., and Machesky, L. M.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: BMC Cell Biology
• Publisher: BMC
• ISSN: 1471-2121
• ISSN (Online): 1471-2121
• Published Online: 07 March 2005
• Copyright Holders: Copyright © 2005 Stovold et al.
• First Published: First published in BMC Cell Biology 6:11
• Publisher Policy: Reproduced under a Creative Commons licence