Derby, S. , Forshaw, M., Lowrie, C., Grose, D., Marashi, H., McLoone, P. , Wilson, C. and McIntosh, D. (2021) Single modality radical radiotherapy is an acceptable alternative for the older patient with squamous cell carcinoma of the oesophagus. BMJ Open Gastroenterology, 8(1), e000492. (doi: 10.1136/bmjgast-2020-000492) (PMID:33504498) (PMCID:PMC7843319)
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Abstract
Background: Oesophageal cancer remains a common cause of cancer mortality worldwide. Increasingly, oncology centres are treating an older population and comorbidities may preclude multimodality treatment with chemoradiotherapy. We review outcomes of radical radiotherapy in an older population treating Squamous Cell Carcinoma (SCC) oesophagus. Methods: Patients over 65 years receiving radiotherapy for SCC oesophagus between 2013-2016 in the West of Scotland were identified. Kaplan-Meier and Cox-regression analysis were used to compare overall survival (OS) between patients treated with radical radiotherapy (RT) and radical chemoradiotherapy (CRT). Results: There were 83 patients over 65 years treated with either RT (n=21) or CRT (n=62). There was no significant difference in median OS between CRT versus RT (26.8 months vs 28.5 months, p=0.92). All patients receiving RT completed their treatment whereas 11% of CRT patients did not complete treatment. Conclusion: Survival in this non-trial older patient group managed with CRT is comparable to that reported in previous trials. RT shows better than expected outcomes which may reflect developments in radiotherapy technique. This review supports RT as an alternative in older patients, unfit for concurrent treatment.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | McLoone, Mr Philip and Grose, Dr Derek and Forshaw, Mr Matthew and Derby, Dr Sarah |
| Authors: | Derby, S., Forshaw, M., Lowrie, C., Grose, D., Marashi, H., McLoone, P., Wilson, C., and McIntosh, D. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | BMJ Open Gastroenterology |
| Publisher: | BMJ Publishing Group |
| ISSN: | 2054-4774 |
| ISSN (Online): | 2054-4774 |
| Published Online: | 27 January 2021 |
| Copyright Holders: | Copyright © Author(s) (or their employer(s)) 2021 |
| First Published: | First published in BMJ Open Gastroenterology 8(1):e000492 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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