Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations

Aubry, F. et al. (2020) Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations. Science, 370(6519), pp. 991-996. (doi: 10.1126/science.abd3663) (PMID:33214283)

Abstract

The drivers and patterns of zoonotic virus emergence in the human population are poorly understood. The mosquito Aedes aegypti is a major arbovirus vector native to Africa that invaded most of the world’s tropical belt over the past four centuries, after the evolution of a “domestic” form that specialized in biting humans and breeding in water storage containers. Here, we show that human specialization and subsequent spread of A. aegypti out of Africa were accompanied by an increase in its intrinsic ability to acquire and transmit the emerging human pathogen Zika virus. Thus, the recent evolution and global expansion of A. aegypti promoted arbovirus emergence not solely through increased vector–host contact but also as a result of enhanced vector susceptibility.

• Item Type: Articles
• Additional Information: Funding: This work was primarily funded by the European Union’s Horizon 2020 research and innovation programme under ZikaPLAN grant agreement no. 734584 (to L.L.). This work was also supported by Agence Nationale de la Recherche (grants ANR-16-CE35-0004-01, ANR-17-ERC2-0016-01, and ANR-18-CE35-0003-01 to L.L.), the French Government’s Investissement d’Avenir program Laboratoire d’Excellence Integrative Biology of Emerging Infectious Diseases (grant ANR-10-LABX-62-IBEID to L.L. and X.M.), the Inception program (Investissement d’Avenir grant ANR-16-CONV-0005 to L.L.), the City of Paris Emergence(s) program in Biomedical Research (to L.L.), the QIMR Berghofer Medical Research Institute (Seed Funding Grant to G.R.), the Programme Opérationnel FEDER-Guadeloupe-Conseil Régional 2014-2020 (grant 2015-FED-192 to A.V.-R.), the European Union's Horizon 2020 research and innovation programme under ZIKALLIANCE grant agreement no. 734548 (to A.V.-R.), the U.S. National Institutes of Health (grant NIDCD R00-DC012069 to C.S.M.), a Helen Hay Whitney Postdoctoral Fellowship (to N.H.R.), the UK Medical Research Council (grant MC_UU_12014/8 to A.K.), and the CDC (J.-P.M.). C.S.M. is a New York Stem Cell Foundation—Robertson Investigator.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Mayanja, Mr Martin and Kohl, Professor Alain
• Authors: Aubry, F., Dabo, S., Manet, C., Filipović, I., Rose, N. H., Miot, E. F., Martynow, D., Baidaliuk, A., Merkling, S. H., Dickson, L. B., Crist, A. B., Anyango, V. O., Romero-Vivas, C. M., Vega-Rúa, A., Dusfour, I., Jiolle, D., Paupy, C., Mayanja, M. N., Lutwama, J. J., Kohl, A., Duong, V., Ponlawat, A., Sylla, M., Akorli, J., Otoo, S., Lutomiah, J., Sang, R., Mutebi, J.-P., Cao-Lormeau, V.-M., Jarman, R. G., Diagne, C. T., Faye, O., Faye, O., Sall, A. A., McBride, C. S., Montagutelli, X., Rašić, G., and Lambrechts, L.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity; College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
• Journal Name: Science
• Publisher: American Association for the Advancement of Science
• ISSN: 0036-8075
• ISSN (Online): 1095-9203
• Copyright Holders: Copyright © 2020 The Authors
• First Published: First published in Science 370(6519):991-996
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher