Alexander, P. G., McMillan, D. C. and Park, J. H. (2021) A meta-analysis of CD274 (PD-L1) assessment and prognosis in colorectal cancer and its role in predicting response to anti-PD-1 therapy. Critical Reviews in Oncology/Hematology, 157, p. 103147. (doi: 10.1016/j.critrevonc.2020.103147) (PMID:33278675)
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Abstract
Background: PD-1 checkpoint inhibitors are novel therapeutic agents in colorectal cancer (CRC). Immunohistochemical staining for CD274 assessment is standardised in upper GI cancer, but not in CRC. Methods: Methodologies of relevant studies were scrutinized and meta-analysis of survival and CD274/PDCD1 performed. Furthermore, anti-PD-1 therapy clinical trial results in CRC were assessed with particular emphasis on CD274 assessment. Results: 24 studies were included. CD274 on immune cells was associated with good prognosis. CD274 on tumour cells has heterogenous outcomes and does not meet requirements of a prognostic marker. As a marker of response to anti-PD-1 therapy, CD274 assessment is not standardised in CRC. Conclusion: CD274 does not appear useful as a prognostic marker. As a marker of response to anti-PD-1 therapy, assessment methodology requires standardisation. As the Combined Positive Score (CPS) is used in upper GI cancer, this seems a logical method to adopt. Thresholds for CRC remain to be determined.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Park, Mr James and Alexander, Mr Peter and McMillan, Professor Donald |
Creator Roles: | Alexander, P. G.Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft McMillan, D. C.Conceptualization, Project administration, Resources, Supervision, Writing – review and editing Park, J. H.Conceptualization, Investigation, Supervision, Writing – review and editing |
Authors: | Alexander, P. G., McMillan, D. C., and Park, J. H. |
College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
Journal Name: | Critical Reviews in Oncology/Hematology |
Publisher: | Elsevier |
ISSN: | 1040-8428 |
ISSN (Online): | 1879-0461 |
Published Online: | 19 November 2020 |
Copyright Holders: | Copyright © 2020 Elsevier B.V. |
First Published: | First published in Critical Reviews in Oncology/Hematology 157: 103147 |
Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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