A meta-analysis of CD274 (PD-L1) assessment and prognosis in colorectal cancer and its role in predicting response to anti-PD-1 therapy

Alexander, P. G., McMillan, D. C. and Park, J. H. (2021) A meta-analysis of CD274 (PD-L1) assessment and prognosis in colorectal cancer and its role in predicting response to anti-PD-1 therapy. Critical Reviews in Oncology/Hematology, 157, p. 103147. (doi: 10.1016/j.critrevonc.2020.103147) (PMID:33278675)

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Abstract

Background: PD-1 checkpoint inhibitors are novel therapeutic agents in colorectal cancer (CRC). Immunohistochemical staining for CD274 assessment is standardised in upper GI cancer, but not in CRC. Methods: Methodologies of relevant studies were scrutinized and meta-analysis of survival and CD274/PDCD1 performed. Furthermore, anti-PD-1 therapy clinical trial results in CRC were assessed with particular emphasis on CD274 assessment. Results: 24 studies were included. CD274 on immune cells was associated with good prognosis. CD274 on tumour cells has heterogenous outcomes and does not meet requirements of a prognostic marker. As a marker of response to anti-PD-1 therapy, CD274 assessment is not standardised in CRC. Conclusion: CD274 does not appear useful as a prognostic marker. As a marker of response to anti-PD-1 therapy, assessment methodology requires standardisation. As the Combined Positive Score (CPS) is used in upper GI cancer, this seems a logical method to adopt. Thresholds for CRC remain to be determined.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Park, Mr James and Alexander, Mr Peter and McMillan, Professor Donald
Creator Roles:
Alexander, P. G.Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft
McMillan, D. C.Conceptualization, Project administration, Resources, Supervision, Writing – review and editing
Park, J. H.Conceptualization, Investigation, Supervision, Writing – review and editing
Authors: Alexander, P. G., McMillan, D. C., and Park, J. H.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Critical Reviews in Oncology/Hematology
Publisher:Elsevier
ISSN:1040-8428
ISSN (Online):1879-0461
Published Online:19 November 2020
Copyright Holders:Copyright © 2020 Elsevier B.V.
First Published:First published in Critical Reviews in Oncology/Hematology 157: 103147
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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