Synovial biopsies in clinical practice and research: current developments and perspectives

Johnsson, H. and Najm, A. (2021) Synovial biopsies in clinical practice and research: current developments and perspectives. Clinical Rheumatology, 40(7), pp. 2593-2600. (doi: 10.1007/s10067-020-05512-7) (PMID:33274415)

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Abstract

Synovial biopsy techniques have developed and widely expanded over the past few years, in particular due to the development of ultrasound-guided procedures. This article reviews the different techniques, clinical applications, and the latest advances in translational research as well as current challenges and perspectives. The first part focuses on different techniques available for biopsy, along with their feasibility, success rate, tolerance, and training requirements. In the second part, clinical applications are described. Data on diagnostic performances are reported, especially regarding septic arthritis. Translational research applications are described and explained in the final part, from the early histological studies and the first description of pathotype to more recent technologies involving -omics. Latest developments involving single-cell RNA sequence analysis have allowed the discovery of new cell subpopulations with remarkable roles in RA pathophysiology. These studies pave the ground for the discovery of new therapeutic targets and the implementation of personalized therapy in RA.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Johnsson, Dr Hanna and Najm, Dr Aurelie
Authors: Johnsson, H., and Najm, A.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Research Centre:College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology
Journal Name:Clinical Rheumatology
Publisher:Springer
ISSN:0770-3198
ISSN (Online):1434-9949
Published Online:04 December 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Clinical Rheumatology 40(7): 2593-2600
Publisher Policy:Reproduced under a Creative Commons License

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