Main, A., Fuller, W. and Baillie, G. S. (2020) Post-translational regulation of cardiac myosin binding protein-C: a graphical review. Cellular Signalling, 76, 109788. (doi: 10.1016/j.cellsig.2020.109788) (PMID:32976931)
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Abstract
Cardiac myosin binding protein-C (cMyBP-C) is a fundamental component of the cardiac sarcomere involved in regulating systolic and diastolic activity, processes which must be tightly maintained to preserve cardiac function. Importantly, as a non-enzymatic protein, cMyBP-C relies solely on post-translational modifications and protein-protein interactions in order to modulate its function, and does so through phosphorylation, glutathionylation and acetylation amongst others. Although some are better understood than others, these modifications may represent novel therapeutic routes to modulate cMyBP-C function in the treatment of cardiac disease.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Fuller, Professor Will and Baillie, Professor George and Main, Alice |
| Authors: | Main, A., Fuller, W., and Baillie, G. S. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Cellular Signalling |
| Publisher: | Elsevier |
| ISSN: | 0898-6568 |
| ISSN (Online): | 1873-3913 |
| Published Online: | 23 September 2020 |
| Copyright Holders: | Copyright © 2020 Elsevier Inc. |
| First Published: | First published in Cellular Signalling 76: 109788 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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