The enigmatic helicase DHX9 and its association with the hallmarks of cancer

Baillie, G. S. , Gulliver, C. and Hoffmann, R. (2021) The enigmatic helicase DHX9 and its association with the hallmarks of cancer. Future Science OA, 7(2), FSO650. (doi: 10.2144/fsoa-2020-0140) (PMID:33437516) (PMCID:PMC7787180)

[img] Text
225723.pdf - Published Version
Available under License Creative Commons Attribution.

2MB

Abstract

Much interest has been expended lately in characterizing the association between DExH-Box helicase 9 (DHX9) dysregulation and malignant development, however, the enigmatic nature of DHX9 has caused conflict as to whether it regularly functions as an oncogene or tumor suppressor. The impact of DHX9 on malignancy appears to be cell-type specific, dependent upon the availability of binding partners and activation of inter-connected signaling pathways. Realization of DHX9’s pivotal role in the development of several hallmarks of cancer has boosted the enzyme's potential as a cancer biomarker and therapeutic target, opening up novel avenues for exploring DHX9 in precision medicine applications. Our review discusses the ascribed functions of DHX9 in cancer, explores its enigmatic nature and potential as an antineoplastic target.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gulliver, Chloe and Baillie, Professor George and Hoffmann, Dr Ralf
Authors: Baillie, G. S., Gulliver, C., and Hoffmann, R.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Future Science OA
Publisher:Future Science
ISSN:2056-5623
ISSN (Online):2056-5623
Published Online:02 November 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Future Science OA 7(2): FSO650
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record